SMILE

Stochastic Models for the Inference of Life Evolution

Presentation

SMILE is an interdisciplinary research group gathering probabilists, statisticians, bio-informaticians and biologists.
SMILE is affiliated to the Stochastics and Biology group of LPSM (Lab of Probability, Statistics and Modeling) at Sorbonne Université (ex Université Pierre et Marie Curie Paris 06).
SMILE is hosted within the CIRB (Center for Interdisciplinary Research in Biology) at Collège de France.
SMILE is supported by Collège de France and CNRS.
Visit also our homepage at CIRB.

Recent contributions of the SMILE group related to SARS-Cov2 and COVID-19.

Directions

SMILE is hosted at Collège de France in the Latin Quarter of Paris. To reach us, go to 11 place Marcelin Berthelot (stations Luxembourg or Saint-Michel on RER B).
Our working spaces are rooms 107, 121 and 122 on first floor of building B1 (ask us for the code). Building B1 is facing you upon exiting the traversing hall behind Champollion's statue.

Contact

You can reach us by email (amaury.lambert - at - upmc.fr) or (smile - at - listes.upmc.fr).

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Publication

2015

Time Reversal Dualities for some Random Forests

We consider a random forest \$$\mathcal{F}^*\$$, defined as a sequence of i.i.d. birth-death (BD) trees, each started at time 0 from a single ancestor, stopped at the first tree having survived up to a fixed time \$$T\$$. We denote by \$$\left(\xi^*_t, 0\leq t \leq T \right)\$$ the population size process associated to this forest, and we prove that if the BD trees are supercritical, then the time-reversed process \$$\left(\xi^*_{T-t}, 0 \leq t \leq T\right)\$$, has the same distribution as \$$\left(\widetilde\xi^*_t, 0 \leq t \leq T\right)\$$, the corresponding population size process of an equally defined forest \$$\widetilde{\mathcal{F}}^*\$$, but where the underlying BD trees are subcritical, obtained by swapping birth and death rates or equivalently, conditioning on ultimate extinction. We generalize this result to splitting trees (i.e. life durations of individuals are not necessarily exponential), provided that the i.i.d. lifetimes of the ancestors have a specific explicit distribution, different from that of their descendants. The results are based on an identity between the contour of these random forests truncated up to \$$T\$$ and the duality property of L\'evy processes. This identity allows us to also derive other useful properties such as the distribution of the population size process conditional on the reconstructed tree of individuals alive at \$$T\$$, which has potential applications in epidemiology.

Upcoming seminars

seminar

TBA

Bastien MALLEIN (U Sorbonne Paris Nord)

June 23, 2020 at 10 - Collège de France


Resources

Planning des salles du Collège de France.
Intranet du Collège de France.